At Cherokee Health Systems, our philosophy is simple. We believe that the best approach to wellness involves treating the mind and body. That’s why we offer an array of comprehensive medical, dental, behavioral health, substance abuse, and medical specialty services to meet the healthcare needs of our East Tennessee neighbors since 1960. Our medical clinics are enhanced to provide first-line treatment for all health conditions including substance use and behavioral health concerns. The interdisciplinary treatment team includes physicians, psychologists, psychiatrists, dentists, case managers, and specialty medical providers who will partner with you to identify and address all of your healthcare needs.

Substance Use Disorders Treatment Approach  

We believe that sobriety is a lifestyle, not simply the absence of substance use. Thus, our healthcare services are comprehensive and aim to promote wellness and healthy lifestyle development. We offer screening, brief behavioral consultation, individual psychotherapy, psychiatric medication management, an Intensive Outpatient Alcohol and Drug Program (IOP), a Relapse Prevention program, and a Crisis Stabilization Unit. Our programs utilize an outpatient abstinence-based model of care; we do not prescribe medication assisted therapies (e.g., Suboxone, Methadone, and Naltrexone) or detox services. 

Program Admissions

 Each Friday afternoon a walk-in clinic is open at 1:30 p.m. for adult IOP intake and admissions at Cherokee Health Systems, 2018 Western Ave., Knoxville, TN, 37921. No appointment is necessary. Call the scheduling line at 866-231-4477 to start your medical records. Cherokee Health Systems accepts all TennCare plans, private insurance and individual pay with a sliding fee scale. Additional grant funding options are available for those who qualify.

We want to be your healthcare partner. For more information, please call 865-525-1661.

Agape Past and Present 

As of July 1, 2015, Agape, Inc. has merged with Cherokee Health Systems to combine Agape’s mission and history with the additional resources provided by Cherokee Health Systems. Agape was established in 1969 to provide halfway houses and treatment for adult women with alcohol and substance use disorders. During its more than 40 years in the community, it has provided important support for the women it served. Cherokee Health Systems has a national reputation and has received national honors for our leading edge development and provision of integrated care. All residents of the former Agape houses now have access to our comprehensive medical, dental, behavioral health, substance abuse, and medical specialty services at Cherokee Health Systems. Pregnant residents have access to women’s health services with prenatal care plus other wrap around services to help prevent Neonatal Abstinence Syndrome (NAS). The three large Victorian style homes located in a historic district of North Knoxville formerly owned by Agape are now operated as housing for women in recovery under the Oxford House model.


The Oxford House is “a concept in recovery from drug and alcohol addiction. In its simplest form, an Oxford House describes a democratically run, self-supporting and drug free home. The number of residents in a House may range from six to fifteen; there are houses for men, houses for women, and houses which accept women with children.”

Click here for more information on Oxford Houses in Knoxville and surrounding areas:


This program is supported in part by the United Way of Greater Knoxville, the Tennessee Department of Mental Health and Substance Abuse Services, other state and federal grant funding and private donations.

Agape, Inc.

428 E. Scott Ave.
Knoxville, TN 37917
Phone: 865.525.1661